A Pilot Study of Continuous Limited-Channel aEEG in Term Infants with Encephalopathy

详细信息    查看全文

• 作者：Russell Lawrence ; Amit Mathur ; Sylvie Nguyen The Tich ; John Zempel ; Terrie Inder
• 刊名：The Journal of Pediatrics
• 出版年：2009
• 出版时间：June 2009
• 年：2009
• 卷：154
• 期：6
• 页码：835-841.e1
• 全文大小：588 K

文摘

Objective

To evaluate the accuracy, feasibility, and impact of limited-channel amplitude integrated electroencephalogram (aEEG) monitoring in encephalopathic infants.

Study design

Encephalopathic infants were placed on limited-channel aEEG with a software-based seizure event detector for 72 hours. A 12-hour epoch of conventional EEG-video (cEEG) was simultaneously collected. Infants were randomly assigned to monitoring that was blinded or visible to the clinical team. If a seizure detection event occurred in the visible group, the clinical team interpreted whether the event was a seizure, based on review of the limited-channel aEEG. EEG data were reviewed independently offline.

Results

In more than 68 hours per infant of limited-channel aEEG monitoring, 1116 seizures occurred (>90 % clinically silent), with 615 detected by the seizure event detector (55 % ). Detection improved with increasing duration of seizures (73 % >30 seconds, 87 % >60 seconds). Bedside physicians were able to accurately use this algorithm to differentiate true seizures from false-positives. The visible group had a 52 % reduction in seizure burden (P = .114) compared with the blinded group.

Conclusions

Monitoring for seizures with limited-channel aEEG can be accurately interpreted, compares favorably with cEEG, and is associated with a trend toward reduced seizure burden.