Local Control of Aldosterone Production and Primary Aldosteronism

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• 作者：Enzo Lalli¹ ; ² ; ³ ; ^{ninino@ipmc.cnrs.fr" class="auth_mail" title="E-mail the corresponding author} ; Jacques Barhanin⁴ ; ⁵ ; Maria-Christina Zennaro⁶ ; ⁷ ; ⁸ ; Richard Warth⁹
• 关键词：adrenal cortex ; aldosterone ; potassium channels ; calcium
• 刊名：Trends in Endocrinology & Metabolism
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：27
• 期：3
• 页码：123-131
• 全文大小：1408 K

文摘

Primary aldosteronism (PA) is caused by excessive production of aldosterone by the adrenal cortex and is determined by a benign aldosterone-producing adenoma (APA) in a significant proportion of cases. Local mechanisms, as opposed to circulatory ones, that control aldosterone production in the adrenal cortex are particularly relevant in the physiopathological setting and in the pathogenesis of PA. A breakthrough in our understanding of the pathogenetic mechanisms in APA has been the identification of somatic mutations in genes controlling membrane potential and intracellular calcium concentrations. However, recent data show that the processes of nodule formation and aldosterone hypersecretion can be dissociated in pathological adrenals and suggest a model envisaging different molecular events for the pathogenesis of APA.