Decreased platelet 5-hydroxytryptamin (5-HT) levels: a response to antidepressants
详细信息 查看全文
- 作者：Xia Lia ; Yuan Fana ; Shifu Xiaoa ; Sufang Penga ; Xiaowei Dongb ; Xianjie Zhengb ; Chia-Chen Liuc ; Huafang Lia ; lhlh_5@163.com" class="auth_mail" title="E-mail the corresponding author ; Zeping Xiaoa ; xiaozeping88@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Depression ; 5-hydroxytryptamine ; Platelet ; Citalopram ; Hippocampus
- 刊名：Journal of Affective Disorders
- 出版年：2015
- 出版时间：15 November 2015
- 年：2015
- 卷：187
- 期：Complete
- 页码：84-90
- 全文大小：528 K
文摘
- listitem" id="list_li0005">
- •
In comparison with control and drug-naïve depressed patients, citalopram-treated patients had significantly lower 5-HT Levels, While Drug-naïve patients had similar 5-HT platelet concentrations as controls.
- •
Consistent with clinical results, the platelet 5-HT level decreased in chronic unpredictable mild stress (CUMS) citalopram-treated rats, in comparison with control and drug-naive CUMS rats.
- •
CUMS+saline rats had high 5-HT level in hippocampus.
- •
The levels of platelet 5-HT did not correlate with neuronal 5-HT levels.
- •
Platelet 5-HT could response to SSRI treatment.