Detention of copper by sulfur nanoparticles inhibits the proliferation of A375 malignant melanoma and MCF-7 breast cancer cells
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- 作者：Hao Liua ; 1 ; Yikai Zhangb ; 1 ; Shanyuan Zhengc ; Zeping Wengd ; Jun Mad ; Yangqiu Lib ; d ; e ; Xinyuan Xiea ; Wenjie Zhenga ; tzhwj@jnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sulfur nanoparticles ; Copper ; Cancer chemotherapy ; Signal transduction ; Combination therapy
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：477
- 期：4
- 页码：1031-1037
- 全文大小：1232 K
文摘
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Nano-S selectively inhibited the mitosis of A375 and MCF-7 cells by depleting copper.
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Nano-S inactivated MEK/ERK pathway through the detention of copper.
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Nano-S improved the cellular uptake and anticancer activities of cisplatin.