Cadmium-induced immune abnormality is a key pathogenic event in human and rat models of preeclampsia
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- 作者：Qiong Zhanga ; joan_zhang2002@sina.com" class="auth_mail" title="E-mail the corresponding author ; Yinping Huangb ; 1 ; yphuangp@126.com" class="auth_mail" title="E-mail the corresponding author ; Keke Zhangb ; zhangkeke0806@126.com" class="auth_mail" title="E-mail the corresponding author ; Yanjun Huangb ; wz5000@126.com" class="auth_mail" title="E-mail the corresponding author ; Yan Yanc ; 1019028268@qq.com" class="auth_mail" title="E-mail the corresponding author ; Fan Wanga ; 413258460@qq.com" class="auth_mail" title="E-mail the corresponding author ; Jie Wub ; wjjw307@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiao Wangb ; 46506149@qq.com" class="auth_mail" title="E-mail the corresponding author ; Zhangye Xua ; 531953862@qq.com" class="auth_mail" title="E-mail the corresponding author ; Yongtao Chenc ; 51325023@qq.com" class="auth_mail" title="E-mail the corresponding author ; Xue Chengc ; 402719092@qq.com" class="auth_mail" title="E-mail the corresponding author ; Yong Lid ; studying@hust.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jinyu Jiaoc ; 402591446@qq.com" class="auth_mail" title="E-mail the corresponding author ; Duyun Yec ; yedy@mails.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Preeclampsia ; Cadmium ; Angiotensin II type 1 receptor agonistic autoantibody ; Activation-induced cytosine deaminase ; Complement
- 刊名：Environmental Pollution
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：218
- 期：Complete
- 页码：770-782
- 全文大小：3919 K
文摘
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The cadmium levels in the peripheral blood of preeclamptic patients were higher than those in normal pregnancy.
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A novel rat model of preeclampsia by injection with low-dose CdCl2 during GD 9-14 was established.
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Cadmium increased AT1-AA level by upregulating activation-induced cytosine deaminase in B cells.
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AT1-AA-mediated AT1 receptor activation is responsible for C5 elevation.
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Elevated C5a contributes to key features of PE seen in the CdCl2-injection model.