Carboxyamidotriazole inhibits oxidative phosphorylation in cancer cells and exerts synergistic anti-cancer effect with glycolysis inhibition
详细信息 查看全文
- 作者：Rui Ju ; Lei Guo ; Juan Li ; Lei Zhu ; Xiaoli Yu ; Chen Chen ; Wei Chen ; Caiying Ye ; caiyingye@126.com" class="auth_mail" title="E-mail the corresponding author ; Dechang Zhang ; zhangdechang45@vip.sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CAI ; carboxyamidotriazole ; OXPHOS ; oxidative phosphorylation ; 2-DG ; 2-deoxyglucose ; LLC ; Lewis lung carcinoma ; RTN ; Rotenone ; SRB ; sulforhodamine B ; OCR ; oxygen consumption rate ; PEG 400 ; polyethylene glycol 400 ; MET ; metformin ; DMSO ; dimethyl sulfoxide
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 January 2016
- 年：2016
- 卷：370
- 期：2
- 页码：232-241
- 全文大小：2627 K
文摘
- •
CAI is confirmed to inhibit OXPHOS in cancer cells for the first time.
- •
Anti-cancer effect of CAI is greatly improved by being combined with 2-DG.
- •
ATP decrease and G2/M arrest are caused by the combination of CAI and 2-DG.
- •
Combination of CAI and 2-DG is well-tolerated and effective in a xenograft model.
- •
Combination of CAI and 2-DG may potentiate other metabolism targeting approaches.