Nobiletin promotes antioxidant and anti-inflammatory responses and elicits protection against ischemic stroke in vivo
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- 作者：Lan Zhanga ; b ; c ; Xiangjian Zhanga ; b ; c ; zhang6xj@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Cong Zhanga ; b ; c ; Xue Baia ; Jian Zhanga ; b ; c ; Xumeng Zhaoa ; b ; c ; Linyu Chena ; b ; c ; Lina Wanga ; b ; c ; Chunhua Zhua ; b ; c ; Lili Cuia ; b ; c ; Rong Chenb ; c ; Ting Zhaoa ; Yuan Zhaoa ; b ; c
- 关键词：Ischemic stroke ; Neuroprotection ; Nobiletin ; Nrf2 ; HO-1 ; NF-κB
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：1636
- 期：Complete
- 页码：130-141
- 全文大小：5657 K
文摘
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Rat middle cerebral artery occlusion model is used to analyze nobiletin׳s effect.
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Nobiletin ameliorates the neurological deficit, brain edema and infarct volume.
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Nobiletin increases Nrf2, HO-1, SOD1 and GSH expression.
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Nobiletin decreases NF-κB, MMP-9 and MDA expression.
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Nobiletin has protective effect in the acute phase of cerebral ischemia.