Rat middle cerebral artery occlusion model is used to analyze nobiletin׳s effect.
Nobiletin ameliorates the neurological deficit, brain edema and infarct volume.
Nobiletin increases Nrf2, HO-1, SOD1 and GSH expression.
Nobiletin decreases NF-κB, MMP-9 and MDA expression.
Nobiletin has protective effect in the acute phase of cerebral ischemia.