Preventive effects of simvastatin nanoliposome on isoproterenol-induced cardiac remodeling in mice

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• 作者：Nuerbiye Tuerdi ; MD^a ; ^b ; ^c ; ¹ ; Lu Xu ; MS^a ; ^b ; ¹ ; Baoling Zhu ; MS^d ; ¹ ; Cong Chen ; MS^a ; ^b ; Yini Cao ; MS^a ; ^b ; Yunan Wang ; PhD^a ; ^b ; Qiang Zhang ; PhD^e ; Zijian Li ; PhD^d ; ^{lzjgy1995@163.com" class="auth_mail" title="E-mail the corresponding author} ; Rong Qi ; PhD^a ; ^b ; ^c ; ^{ronaqi@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; ^{ronaqi@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Simvastatin ; Nanoliposome ; Isoproterenol ; Cardiac remodeling ; Bioavailability
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：12
• 期：7
• 页码：1899-1907
• 全文大小：1572 K

文摘

In this study, simvastatin (SMV) and SMV nanoliposome (SMV-Lipo) were given to male BALB/c mice by either intragastric (i.g.) or intraperitoneal (i.p.) administration, and their effects on isoproterenol (ISO)-induced cardiac remodeling were compared. The results indicate that by i.p. administration, the SMV-Lipo at an equal SMV dose exhibited more significant inhibitory effects than the crude SMV on cardiac hypertrophy, fibrosis and inflammation. Comparing the SMV-Lipo on different administration regimens, i.p. group showed more significant inhibitory effects on cardiac remodeling than i.g. group. In addition, pharmacokinetic studies revealed that SMV-Lipo administrated by either i.p. or i.g. more significantly improved the plasma SMV concentration than the crude SMV. Therefore, the SMV-Lipo significantly enhanced the inhibitory effects of SMV on cardiac remodeling resulted from the enhanced absorption of SMV by nanoliposome formulation, and i.p. was better than i.g. administration.