Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages
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- 作者：Juan Xiang ; Si Cheng ; Tianlong Feng ; Yan Wu ; Weina Xie ; Mian Zhang ; mianzhang@126.com" class="auth_mail" title="E-mail the corresponding author ; Xianghong Xu ; Chaofeng Zhang ; njchaofeng@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neotuberostemonine ; Stemona tuberosa ; Pulmonary fibrosis ; Macrophage ; M2 polarization
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：36
- 期：Complete
- 页码：158-164
- 全文大小：1833 K
文摘
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Neotuberostemonine (NTS) greatly attenuated pulmonary fibrosis induced by bleomycin.
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NTS significantly relieved macrophage infiltration in bleomycin-induced lung tissue.
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NTS mainly inhibited the M2, rather than M1, polarization both in vivo and in vitro.