Cooperative Action between SALL4A and TET Proteins in Stepwise Oxidation of 5-Methylcytosine

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• 作者：Jun Xiong¹ ; ⁸ ; Zhuqiang Zhang¹ ; ⁸ ; ^{zhangzhuqiang@ibp.ac.cn} ; Jiayu Chen² ; Hua Huang³ ; Yali Xu⁴ ; Xiaojun Ding⁴ ; Yong Zheng¹ ; Ryuichi Nishinakamura⁵ ; Guo-Liang Xu⁶ ; Hailin Wang³ ; She Chen⁴ ; Shaorong Gao² ; Bing Zhu¹ ; ⁷ ; ⁹ ; ^{zhubing@ibp.ac.cn}
• 关键词：SALL4 ; TET1 ; TET2 ; DNA methylation ; oxidation ; enhancer
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：64
• 期：5
• 页码：913-925
• 全文大小：8139 K
• 卷排序：64

文摘

A SILAC-assisted DNA pull down reveals SALL4A preferentially binds 5hmC in vitro SALL4A occupies enhancers in mouse ESCs, largely in a TET1-dependent manner SALL4A facilitates 5hmC further oxidation at its binding sites TET2 is the main enzyme catalyzing 5hmC further oxidation at SALL4A-binding sites