New synthetic strategy for chiral 2-oxazolidinones derivatives via rhodium-catalyzed asymmetric hydrogenation

详细信息    查看全文

• 作者：Qingli Wang^&dagger ; ; Xuefeng Tan^&dagger ; ; Ziyue Zhu ; Xiu-Qin Dong ; ^{xiuqindong@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xumu Zhang ; ^{xumu@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Asymmetric hydrogenation ; Enantioselectivity ; Rh-catalyzed ; Phosphine ligand ; Chiral 2-oxazolidinones
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：10 February 2016
• 年：2016
• 卷：57
• 期：6
• 页码：658-662
• 全文大小：766 K

文摘

Asymmetric hydrogenation of 4-substituted cyclic enamido esters catalyzed by a rhodium–TangPhos complex provides an efficient method for the synthesis of chiral 4-substituted oxazolinones with excellent yields and good enantioselectivities. The products are valuable chiral building blocks and the applications as chiral auxiliaries and pharmaceuticals are well-known.