Metformin improves lipid metabolism disorders through reducing the expression of microsomal triglyceride transfer protein in OLETF rats

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• 作者：Nianhong Wang^a ; Junqing Zhang^b ; ^{junqingzhang126@126.com} ; Yiming Wu^b ; Jia Liu^b ; Lin Liu^b ; Xiaohui Guo^b
• 关键词：Microsomal triglyceride transfer protein ; Hypertriglyceridemia ; Type 2 diabetes mellitus ; Insulin-resistant ; Otsuka Long Evans Tokushima Fatty (OLETF) rats
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：122
• 期：Complete
• 页码：170-178
• 全文大小：1340 K
• 卷排序：122

文摘

Type 2 diabetes mellitus are associated with lipid metabolism disorders which the pathogenic mechanism is not clear. In this study, increased expression of microsomal triglyceride transfer protein (MTP) was found in the liver of Otsuka Long Evans Tokushima Fatty (OLETF) rats. It suggested that MTP might be associated with the lipid metabolism disorder in OLETF rats. Metformin, as the first-line medication for the treatment of type 2 diabetes, could improve lipid metabolism through reducing the expression of MTP.