Iguratimod (T-614) suppresses RANKL-induced osteoclast differentiation and migration in RAW264.7 cells via NF-κB and MAPK pathways
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- 作者：Ke Gana ; b ; 1 ; Leilei Yanga ; 1 ; Lingxiao Xua ; Xiaoke Fengc ; Qiande Zhangc ; Fang Wangd ; Wenfeng Tana ; tw2006@njmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Miaojia Zhanga ; miaojia_zhang@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Iguratimod ; Osteoclast ; RANKL ; Differentiation ; Function ; Migrations
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：294-300
- 全文大小：1011 K
文摘
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a directly inhibitory role of Iguratimod on osteoclast formation and function, which is distinct from previous report
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Iguratimod significantly inhibits osteoclast precursors migration induced by RANKL
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Iguratimod significantly inhibits osteoclastic related transcription factors of c-Fos, c-JUN and NFATc1