Role of PDGF-D and PDGFR-β in neuroinflammation in experimental ICH mice model
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- 作者：Peng Yanga ; d ; 1 ; yangpeng@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Anatol Manaenkod ; l ; 1 ; anatolmanaenko@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Feng Xua ; 1 ; sz_xf@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Liyan Miaob ; miaolysuzhou@163.com" class="auth_mail" title="E-mail the corresponding author ; Gaiqing Wangd ; i ; wanggq08@163.com" class="auth_mail" title="E-mail the corresponding author ; Xuezhen Huj ; 649321276@qq.com" class="auth_mail" title="E-mail the corresponding author ; Zhen-Ni Guod ; k ; zhen1ni2@163.com" class="auth_mail" title="E-mail the corresponding author ; Qin Hud ; huqinle@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Richard E. Hartmang ; behavioralneuroscience@gmail.com" class="auth_mail" title="E-mail the corresponding author ; William J. Pearced ; wpearce@llu.edu" class="auth_mail" title="E-mail the corresponding author ; Andre Obenaush ; aobenaus@llu.edu" class="auth_mail" title="E-mail the corresponding author ; John H. Zhangd ; e ; f ; johnzhang3910@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Gang Chenc ; nju_neurosurgery@163.com" class="auth_mail" title="E-mail the corresponding author ; Jiping Tangd ; jtang@llu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PDGF-D ; PDGFR-β ; ICH ; Neuroinflammation
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：283
- 期：part_PA
- 页码：157-164
- 全文大小：1449 K
文摘
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ICH increased PDGF-D expression and macrophage infiltration.
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PDGFR-inhibition decreased ICH-induced brain injury.
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Recombinant PDGF-D induced TNF-α production and PDGFR-inhibition attenuated it.
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A plasmin-antagonist suppressed activation of PDGFR-β and microglia.
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Plasmin increased PDGF-D expression.
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PDGF-D inhibition reduced neutrophil infiltration.