Trans-cinnamaldehyde improves memory impairment by blocking microglial activation through the destabilization of iNOS mRNA in mice challenged with lipopolysaccharide
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- 作者：Liqing Zhanga ; 1 ; Zhangang Zhanga ; 1 ; Yan Fua ; 1 ; Pin Yanga ; Zhenxia Qinb ; Yongjun Chenc ; Ying Xua ; ying6122003@aliyun.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Trans-cinnamaldehyde ; Neuroinflammation ; Microglial activation ; Memory impairment ; iNOS mRNA stability ; MEK1/2-ERK1/2 signaling pathway
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：110
- 期：part_PA
- 页码：503-518
- 全文大小：4499 K
文摘
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TCA exhibits neuroprotective effect and improves memory deficit by suppressing neuroinflammation and microglial activation.
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TCA decreases NO production by accelerating the degradation of iNOS mRNA through the interruption of MEK1/2-ERK1/2 pathway.
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TCA represents as a potent therapeutic agent against neuroinflammatory and neurodegenerative disorders.