A composited PEG-silk hydrogel combining with polymeric particles delivering rhBMP-2 for bone regeneration
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- 作者：Dakun Maa ; 1 ; Gang Ana ; 1 ; Min Liangb ; Yugang Liuc ; Bin Zhangd ; zhangbhyd@126.com" class="auth_mail" title="E-mail the corresponding author ; Yansong Wanga ; d ; e ; wangyansong1975@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hydrogel ; Bio-composite ; BMP-2 sustained release ; Bone regeneration
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：221-231
- 全文大小：3147 K
文摘
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The method is simpler, safer, more time-saving and cost-effective.
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Composited gels are biocompatible and show good physicochemical properties.
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Composited gels deliver drugs spatiotemporally and stabilize their bio-activity simultaneously.
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In vivo, composited gels release BMP-2 locally to promote bone regeneration at a low dose of rhBMP-2.
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Composited optimized gels can deliver other drugs for different tissue repairs and medical applications.