HuAECs reduced proliferation rate of patient-derived CD4+ T cells. HuAECs reduced IL-2 released from patient-derived CD4+ T cells. Overexpressed miR-101 reduced expression c-Rel and IL-2 in AKI patient-derived CD4+ T cells. Overexpressed miR-101 decreased binding capacities of ‘c-Rel-NFκB’ complex on IL-2 promoter. HuAECs stimulate miR-101 expression to inhibit AKI patient-derived CD4+ T cells activation.