Role of surgery in the treatment of patients with high-risk neuroblastoma who have a poor response to induction chemotherapy

详细信息    查看全文

• 作者：Lei Du^a ; ^b ; ¹ ; Ling Liu^c ; ¹ ; Chi Zhang^c ; ^{zhangchi31@126.com" class="auth_mail} ; Wei Cai^a ; ^b ; ^{caiw1978@163.com" class="auth_mail} ; Yeming Wu^a ; Jun Wang^a ; Fan lv^a
• 关键词：Neuroblastoma ; Surgical intervention ; Survival ; Postoperative complications
• 刊名：Journal of Pediatric Surgery
• 出版年：April, 2014
• 年：2014
• 卷：49
• 期：4
• 页码：528-533
• 全文大小：708 K

文摘

Background

In instances of high-risk neuroblastoma that do not show a clinical response to induction therapy, whether it is worth performing surgical resection or not and whether gross total resection (GTR) is more important than subtotal resection (STR) remain controversial.

Methods

We retrospectively analyzed the data of patients with stage 4 neuroblastoma aged 18 months or older at diagnosis. Primary tumor volumes were measured both at diagnosis and at the first tumor response evaluation (after 6 cycles of induction chemotherapy). If the tumor volume at the first response evaluation was > 50% of the initial tumor volume, the patient was categorized as a poor responder. Otherwise, the patient was categorized as a good responder. Only poor responders were included. Patients were evaluated for event-free survival (EFS), overall survival (OS), and complications of surgery based on extent of surgical intervention.

Results

Sixty-five patients were included in this study. The 41 patients who underwent surgical intervention had a higher 3-year OS than the 24 patients who had a biopsy only (55.4% 卤 8.1% vs. 31.3% 卤 10.2%, P = 0.02). However, there was limited improvement in 3-year EFS following surgical intervention. Three-year EFS rates of BX group (biopsy only) and OP group (surgical resection) were 24.2% 卤 9.3% and 37.7% 卤 7.9%, respectively (P = 0.063). The extent of resection had no impact on 3-year OS (P = 0.631) and 3-year EFS (P = 0.796). Patients in the GTR group trended to have more severe surgical complications than patients in the STR group (P = 0.105).

Conclusions

For high-risk neuroblastomas that do not show a clinical response to induction therapy, surgical resection is important in predicting outcome, but the extent of resection is not.