Self-reported smoking, serum cotinine, and blood DNA methylation
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- 作者：Yan Zhanga ; y.zhang@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; y.zhang@dkfz.de" class="auth_mail" title="E-mail the corresponding author ; Ines Floratha ; ines.florath@curtin.edu.au" class="auth_mail" title="E-mail the corresponding author ; Kai-Uwe Sauma ; k.saum@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Hermann Brennera ; b ; c ; h.brenner@dkfz-Heidelberg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA methylation ; Epigenome-wide association study ; Smoking ; Cotinine ; Dose-response relationship
- 刊名：Environmental Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：395-403
- 全文大小：1371 K
文摘
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Cotinine and methylation showed non-linear relationships with self-reported smoking intensity.
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A clear linear relationship between cotinine and methylation level was disclosed.
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Both cotinine and methylation markers accurately distinguished current from never smoker.
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Only methylation markers distinguished former from never smoker with high accuracy.