Expression of heat shock protein 27 correlates with actin cytoskeletal dynamics and contractility of cultured human bladder smooth muscle cells
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- 作者：Yongquan Wang ; Zhiyong Xiong ; Wei Gong ; Peng Zhou ; Qiubo Xie ; Zhansong Zhou ; zhansong898@yeah.net" class="auth_mail" title="E-mail the corresponding author ; Gensheng Lu ; lugeng8@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HSP27 ; Bladder smooth muscle cells ; Actin cytoskeleton ; Contraction
- 刊名：Experimental Cell Research
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：338
- 期：1
- 页码：39-44
- 全文大小：4129 K
文摘
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Heat shock protein 27 (HSP27) modulates smooth muscle contraction.
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Overexpression of HSP27 promoted cells recovered from stretching.
Moreover, the contraction protection function of HSP27 may depend on the activation of phosphorylation of Ser 78 and 82
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Overexpression of HSP27 significantly increased F/G-actin ratio after stretching.
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HSP27 plays pivotal role in regulating bladder smooth muscle contraction.