Plasma miR-1, miR-208, miR-499 as potential predictive biomarkers for acute myocardial infarction: An independent study of Han population
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- 作者：Xian Liua ; 1 ; Zhanwei Fanb ; 1 ; Tianshu Zhaoc ; Wei Caod ; Lan Zhanga ; He Lia ; Qing Xiee ; Ye Tianf ; drtianye01@yeah.net" class="auth_mail" title="E-mail the corresponding author ; Baichun Wangb ; zhan_jinjin@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMI ; acute myocardial infarction ; ROC ; receiver operating characteristic ; miRNAs ; microRNAs ; qRT-PCR ; quantitative reverse transcription-polymerase chain reaction ; SROC ; summary receiver operating characteristic ; AUC ; the area under the curve ; PLR ; positive likelihood ratio ; NLR ; negative likelihood ratio ; DOR ; diagnostic odds ratio
- 刊名：Experimental Gerontology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：72
- 期：Complete
- 页码：230-238
- 全文大小：1072 K
文摘
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The expressions of plasma miR-1, -208, -499 were significantly elevated in AMI.
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Plasma miR-1 was evaluated with an AUC value of 0.81 for the prediction of AMI.
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Plasma miR-208 was evaluated with an AUC value of 0.72 for the prediction of AMI.
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Plasma miR-499 was evaluated with an AUC value of 0.88 for the prediction of AMI.
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MiR-208 and miR-499 were supposed to be more reliable as biomarkers in AMI screening.