Effect of ZBD-2 on chronic pain, depressive-like behaviors, and recovery of motor function following spinal cord injury in mice

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• 作者：Xiao-ming Li^a ; ¹ ; Jia Meng^a ; ¹ ; Lin tao Li^a ; ¹ ; Ting Guo^a ; ¹ ; Liu-kun Yang^b ; Qi-xin Shi^b ; Xu-bo Li^b ; Yong Chen^a ; ^{13813889089@139.com} ; Qi Yang^b ; ^{yangqifmmu@126.com} ; Jian-ning Zhao^a ; ^{jnzhao2002@163.com}
• 关键词：Pain ; Depression ; Microglia ; Spinal cord injury
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：30 March 2017
• 年：2017
• 卷：322
• 期：part_PA
• 页码：92-99
• 全文大小：2750 K
• 卷排序：322

文摘

ZBD-2 significantly attenuated the symptoms of chronic SCI-pain and pain-induced depressive-like behaviors. ZBD-2 inhibited the decreases in the expression of synaptic plasticity-related signaling proteins. ZBD-2 reversed chronic, SCI-induced gliocyte activation at the lesion site.