Peroxiredoxin 1-mediated activation of TLR4/NF-κB pathway contributes to neuroinflammatory injury in intracerebral hemorrhage

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• 作者：Dong-Ling Liu ; Li-Xue Zhao ; Shuang Zhang ; Jun-Rong Du ; ^{dujr_1@163.com}
• 关键词：Peroxiredoxins (Prxs) ; Hemorrhagic stroke ; Neuroinflammation ; Immunomodulation ; TLR4/NF-κB pathway
• 刊名：International Immunopharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：41
• 期：Complete
• 页码：82-89
• 全文大小：754 K
• 卷排序：41

文摘

Peroxiredoxin1 (Prx1) induced TLR4/NF-κB activation and inflammation in macrophages. Hemorrhagic stress stimulated expression and spillage of Prx1in brain. Prx1-mediated TLR4/NF-κB activation was involved in post-hemorrhage brain injury.