Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cells, Leading to Bohring-Opitz-like Syndrome in Mice
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- 作者：Peng Zhang1 ; 8 ; Caihong Xing2 ; 3 ; 8 ; Steven D. Rhodes4 ; Yongzheng He4 ; Kai Deng1 ; 9 ; Zhaomin Li1 ; Fuhong He2 ; Caiying Zhu2 ; 5 ; Lihn Nguyen4 ; Yuan Zhou5 ; Shi Chen1 ; Khalid S. Mohammad6 ; Theresa A. Guise6 ; Omar Abdel-Wahab7 ; Mingjiang Xu1 ; Qian-Fei Wang2 ; wangqf@big.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Feng-Chun Yang1 ; fxy37@med.miami.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bohring-Opitz syndrome ; ASXL1 mutation ; bone marrow stromal cell ; self-renewal and differentiation ; skeletal development
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：14 June 2016
- 年：2016
- 卷：6
- 期：6
- 页码：914-925
- 全文大小：999 K
文摘
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Asxl1 loss impairs BMSC self-renewal and cell fate
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Asxl1 loss leads to dramatic bone loss
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Asxl1 loss alters the expression of genes critical for cell fates of BMSCs
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Re-introducing Asxl1 restores self-renewal and lineage commitment in Asxl1−/− BMSCs