- 作者：Qingke Bai ; MS&lowast ; ; Zhenguo Zhao ; MS&dagger ; ; zhaozhenguo1@sina.com" class="auth_mail ; Haijing Sui ; MS&dagger ; ; Xiuhai Xie ; MS&dagger ; ; Juan Chen ; MS&lowast ; ; Juan Yang ; MS&lowast ; ; Yuan Zhou ; PhD&lowast ;
- 关键词：Magnetic resonance imaging ; stroke ; recombinant tissue plasminogen activator ; thrombolysis
- 刊名：Journal of Stroke and Cerebrovascular Diseases
- 出版年：April, 2014
- 年：2014
- 卷：23
- 期：4
- 页码：e263-e269
- 全文大小：967 K
Background
The aim of this study is to investigate the outcomes of magnetic resonance imaging (MRI)-based individual thrombolysis therapy using recombinant tissue plasminogen activator (rt-PA) in patients with superacute infarction, comparing the outcome in 1 group of patients treated within 4.5聽hours compared with 4.5- to 12-hour window treatment group.Methods
We studied 135 patients stratified to 2 different groups based on whether they presented with stroke symptoms within 4.5聽hours (4.5-hour group, 72 patients) or between 4.5 and 12聽hours (4.5- to 12-h group, 63 patients). All patients were treated with rt-PA after MRI confirmed superacute ischemic stroke (hyperintense in diffusion-weighted imaging but no hypointense change in T2-weighted image (T2WI) or fluid-attenuated inversion recovery). Clinical neurologic deficit was evaluated using the National Institutes of Health Stroke Scale on admission, at 24聽hours, and 7聽days later. A 90-day clinical outcome was assessed using the modified Rankin Scale (mRS).
Results
There was no significant difference in the clinical outcome between the patients treated with thrombolysis within the first 4.5聽hours and those treated between 4.5 and 12聽hours. The 2 groups both had recanalization, mRS, and favorable outcome at 90聽days (P聽>聽.05).
Conclusions
Our study suggested that fast MR-based thrombolysis using rt-PA was safe and reliable in superacute infarction within 4.5聽hours and 4.5-12聽hours poststroke.