Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy
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- 作者：Fan Wu1 ; 5 ; Yasunori Watanabe2 ; 5 ; Xiang-Yang Guo3 ; 5 ; Xin Qi1 ; 5 ; Peng Wang4 ; Hong-Yu Zhao1 ; Zheng Wang1 ; Yuko Fujioka2 ; Hui Zhang1 ; Jin-Qi Ren1 ; Tian-Cheng Fang3 ; Yu-Xian Shen4 ; Wei Feng1 ; Jun-Jie Hu1 ; 6 ; Nobuo N. Noda2 ; nn@bikaken.or.jp" class="auth_mail" title="E-mail the corresponding author ; Hong Zhang1 ; 6 ; hongzhang@sun5.ibp.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：aggrephagy ; autophagosome ; lgg-1 ; lgg-2 ; Atg8
- 刊名：Molecular Cell
- 出版年：2015
- 出版时间：17 December 2015
- 年：2015
- 卷：60
- 期：6
- 页码：914-929
- 全文大小：7374 K
文摘
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The N-terminal tails of LGG-1 and LGG-2 adopt unique closed and open forms
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lgg-2 exhibits temporal-specific and cargo-specific functions in autophagy
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LGG-1 and LGG-2 differentially interact with autophagy substrates and ATG proteins
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Lipidated LGG-1 and LGG-2 exhibit different membrane tethering and fusion activity