Comparison between amine-terminated phthalocyanines and their chlorambucil conjugates: Synthesis, spectroscopic properties, and in vitro anticancer activity
Two novel phthalocyanine-CLB conjugates (5 and 7) have been synthetized. The structure-activity relationships of these compounds have been discussed. 6 and 7 show weaker singlet oxygen generation efficiency than that of 4 and 5. Compound 6 shows the highest photocytotoxicity against HepG2 cells (IC50 = 9 nM).