Changes of TSPO-mediated mitophagy signaling pathway in learned helplessness mice
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- 作者：Dongmei Li1 ; Ji Zheng1 ; Mingyang Wang ; Lu Feng ; Zhili Ren ; Yanyong Liu ; liuyanyong@126.com" class="auth_mail" title="E-mail the corresponding author ; Nan Yang ; yangnanbeijing@126.com" class="auth_mail" title="E-mail the corresponding author ; Pingping Zuo
- 关键词：Depression ; Learned helplessness ; Mitochondrial autophagy ; 18 ; kDa translocator protein ; Voltage-dependent anion channel
- 刊名：Psychiatry Research
- 出版年：2016
- 出版时间：30 November 2016
- 年：2016
- 卷：245
- 期：Complete
- 页码：141-147
- 全文大小：1569 K
文摘
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TSPO expression significantly decreased in the brain of LH mice.
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Several TSPO downstream mitophagy signal molecules were also down-regulated.
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TSPO may be potential therapeutic target for depression treatment.