Activated cathepsin L is associated with the switch from autophagy to apoptotic death of SH-SY5Y cells exposed to 6-hydroxydopamine
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- 作者：Lingyun Lia ; b ; lingyunlee@126.com" class="auth_mail" title="E-mail the corresponding author ; Luyan Gaob ; Yunzhen Songa ; Zheng-Hong Qina ; Zhongqin Lianga ; liangzhongqin@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：6-Hydroxydopamine ; Cathepsin L ; Autophagy ; Apoptosis ; Neurodegeneration
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：12 February 2016
- 年：2016
- 卷：470
- 期：3
- 页码：579-585
- 全文大小：1614 K
文摘
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Inhibition of autophagy aggravated the cell apoptotic death in SH-SY5Y cells.
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Activation of cathepsin L impaired the autophagy pathway.
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Activation of cathepsin L enhanced the cell apoptotic cascade.
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Cathepsin L involves in the cross talk between autophagy and apoptosis.