Screening and identification of a specific peptide for targeting hypoxic hepatoma cells
详细信息 查看全文
- 作者：Yiming Liu1 ; Xiangwen Xia1 ; Yong Wang ; Xin Li ; Guofeng Zhou ; Huiming Liang ; Gansheng Feng ; Chuansheng Zheng ; hqzcsxh@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatoma cell ; TACE ; Hypoxia ; Phage display ; Peptide
- 刊名：Molecular and Cellular Probes
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：30
- 期：4
- 页码：246-253
- 全文大小：1645 K
文摘
- •
A heptapeptide that bind specifically to hypoxic hepatoma cells is reported.
- •
We use a phage display peptide library for in vivo and in vitro screening to obtain this pepetide.
- •
The binding assay indicated that the heptapeptide could specifically bind to hypoxic hepatoma cells and hepatocarcinoma tissues.
- •
The peptide has the potential to be a useful targeting ligand for residual hepatoma cells after TACE.