Tuberculosis-sensitized monocytes sustain immune response of interleukin-37

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• 作者：Jun-Ai Zhang^a ; ^c ; ¹ ; Gan-Bin Liu^b ; ¹ ; Bi-Ying Zheng^a ; ¹ ; Yuan-Bin Lu^a ; ^c ; Yu-Chi Gao^a ; ^c ; Xiao-Zhen Cai^d ; You-Chao Dai^a ; ^c ; Shi-Yan Yu^a ; ^c ; Yan Jia^a ; ^c ; Chen Chen^a ; ^c ; Ze-Gang Zhuang^a ; ^c ; Xin Wang^a ; ^c ; Wan-Dang Wang^a ; ^e ; Xiao-Xia Fu^a ; Lai-Long Yi^b ; Ling Shen^e ; Zheng W. Chen^e ; Jun-Fa Xu ; Dr.^a ; ^c ; ^{xujunfa@gdmu.edu.cn}
• 关键词：IL-37b ; Monocytes ; Cytokines ; Innate immunity ; Active tuberculosis
• 刊名：Molecular Immunology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：79
• 期：Complete
• 页码：14-21
• 全文大小：2244 K
• 卷排序：79

文摘

IL-37b production in ATB appear to associate with prolonged/complicated TB, TB burdens and inflammatory reactions, and negatively correlate with immune responses of pro-inflammatory cytokines. While mycobacterial re-infection of monocytes from TB patients, but not BCG-vaccinated HC, enhances or sustains IL-37b production, TB-sensitized monocytes from TB patients mount more robust immune responses of IL-37b than pre-inflammatory cytokines, with negative correlation, during mycobacterial re-infection in culture. TB-sensitized monocytes from TB patients mounted more robust immune responses of IL-37b than those of pre-inflammatory cytokines during mycobacterial re-infection in culture. Our data represent new findings in terms of IL-37b responses, immune correlates and potential mechanisms in TB patients. Our data are somehow consistent with the early report that IL-37 is expressed at a very low level in steady-state target cells and tissues of humans without Mtb infection, although published studies showed that IL-37b could be produced under circumstances by various types of cells, including PBMCs, epithelial cells, macrophages, dendritic cells (DCs) and T cells.