Specific histone modification responds to arsenic-induced oxidative stress
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- 作者：Lu Maa ; 1 ; Jun Lib ; 1 ; Zhengbao Zhana ; 1 ; Liping Chena ; Daochuan Lia ; Qing Baia ; Chen Gaoa ; Jie Lia ; Xiaowen Zenga ; Zhini Hea ; Shan Wanga ; Yongmei Xiaoa ; Wen Chena ; chenwen@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Aihua Zhangb ; aihuagzykd@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：OSR ; oxidative stress response
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：302
- 期：Complete
- 页码：52-61
- 全文大小：791 K
文摘
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H3K18ac, H3K9me2 and H3K36me3 were associated with arsenic exposed levels.
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H3K18ac and H3K36me3 were correlated with oxidative damage induced by arsenic.
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H3K18ac and H3K36me3 might involve in transcriptional regulation of OSR genes.
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Dysregulation of H3K18ac and H3K36me3 might be biomarkers of arsenic toxicity.