High fat diet triggers cell cycle arrest and excessive apoptosis of granulosa cells during the follicular development
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- 作者：Yanqing Wu ; Zhenghong Zhang ; Xinghui Liao ; Zhengchao Wang ; zcwang@fjnu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：High fat diet ; Follicular development ; Granulosa cells ; Cell cycle arrest ; Apoptosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：23 October 2015
- 年：2015
- 卷：466
- 期：3
- 页码：599-605
- 全文大小：2345 K
文摘
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HFD induced-obesity leads to abnormal ovarian morphology.
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HFD induced-obesity triggers excessive apoptosis in the ovary.
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HFD induced-obesity up-regulates cell cycle inhibitors p21Cip1 and p27Kip1 in the ovary.
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HFD induced-obesity causes cell cycle arrest in the ovary.