De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation
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- 作者：Matilda A. Haas1 ; 8 ; Linh Ngo1 ; 2 ; 8 ; Shan Shan Li1 ; Sibylle Schleich3 ; Zhengdong Qu1 ; Hannah K. Vanyai2 ; Hayley D. Cullen2 ; Aida Cardona-Alberich4 ; Ivan E. Gladwyn-Ng1 ; 2 ; Alistair T. Pagnamenta5 ; Jenny C. Taylor5 ; Helen Stewart6 ; Usha Kini6 ; Kent E. Duncan4 ; Aurelio A. Teleman3 ; David A. Keays7 ; Julian I.-T. Heng1 ; 2 ; julian.heng@perkins.uwa.edu.au" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：7 June 2016
- 年：2016
- 卷：15
- 期：10
- 页码：2251-2265
- 全文大小：5717 K
文摘
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DENR is an important player in mammalian neurodevelopment
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DENR controls radial migration through its binding partner MCTS1
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Mutations in DENR influence neuronal positioning and neurodifferentiation
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This study links impaired mRNA translation re-initiation to neurological disorders