Molecular validation of the precision-cut kidney slice (PCKS) model of renal fibrosis through assessment of TGF-β1-induced Smad and p38/ERK signaling
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- 作者：Shouhua Zhangb ; d ; 1 ; Queling Liuc ; 1 ; Juhua Xiaoe ; Jun Leid ; Yi Liua ; Hongyan Xud ; Zhengdong Honga ; ndefy01@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Precision-cut kidney slice ; PCKS ; Renal fibrosis ; Smad ; Smad2 ; Smad3 ; Smad7 ; ERK ; p38
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：34
- 期：Complete
- 页码：32-36
- 全文大小：573 K
文摘
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This study investigated the molecular validity of the precision-cut kidney slice (PCKS) model.
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The PCKS model demonstrated significant p-Smad2 and p-Smad3 upregulation relative to control.
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The model showed higher Smad2/3 complex formation and nuclear translocation relative to control.
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The model showed significant p-ERK1, p-ERK2, and p-p38 MAPK upregulation relative to control.
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The PCKS model displays several well-established molecular markers of renal fibrosis.