Asymmetric [4+2] cycloadditions employing 1,3-dienes derived from (R

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• 作者：Zhengmao Hua ; Lei Chen ; Yan Mei ; Zhendong Jin
• 刊名：Tetrahedron Letters
• 出版年：2009
• 出版时间：2 December 2009
• 年：2009
• 卷：50
• 期：48
• 页码：6621-6623
• 全文大小：914 K

文摘

1,3-Dienes derived from (R)-4-t-butyldimethylsilyloxy-2-cyclohexen-1-one react with activated dienophiles to form predominately (or sometimes exclusively) syn/endo products. These controlled [4+2] cycloadditions increase the asymmetric complexity from one asymmetric center in the starting material to five asymmetric centers in the products in a single step, and provide a powerful approach for the asymmetric synthesis of compounds containing the bicyclo[2.2.2]octanone carbon skeleton.