Extracts and lignans of Schisandra chinensis fruit alter lipid and glucose metabolism in vivo and in vitro
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- 作者：Haitao Liu1 ; Chongming Wu1 ; Shuai Wang ; Shiman Gao ; Jiushi Liu ; Zhengqi Dong ; Bengang Zhang ; bgzhang@implad.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Mingyue Liu ; Xiaobo Sun ; Peng Guo ; pguo@implad.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：SF ; S.&thinsp ; chinensis fruit ; HFD ; high-fat diet ; XZK ; xuezhikang tablet ; SDC ; schisandrin C ; HDL-c ; high density lipoprotein cholesterol ; LDL-c ; low density lipoprotein cholesterol ; TC ; total cholesterol ; TG ; triacylglycerol ; OGTT ; oral glucose tolerance test ; PPARα ; peroxisome proliferator-activated receptor ; CPT-1 ; carnitine palmitoyl transterase-1 ; SREBPs ; sterol regulatory element-binding proteins ; AMPK ; AMP-activated protein kinase ; ACC ; acetyl-CoA carboxylase ; HMGR ; 3-hydroxy-3-methylglu
- 刊名：Journal of Functional Foods
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：19
- 期：part_PA
- 页码：296-307
- 全文大小：2835 K
文摘
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Schisandra chinensis fruit extract (SZD) decreases serum/hepatic lipids.
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SZD upregulates PPARα and AMPK and downregulates SREBPs.
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Lignans are the major contributor to lipid-lowering activity of SZD.
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Schisandrin C is potent in decreasing TC and TG levels in both HepG2 hepatocytes and Triton WR-1339 induced hyperlipidaemic mice.