Estradiol mediates vasculoprotection via ERRα-dependent regulation of lipid and ROS metabolism in the endothelium
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- 作者：Huawen Lia ; 1 ; Zhaoyu Liub ; 1 ; Yulan Gouc ; Haibing Yua ; Stavros Siminelakisd ; Shixuan Wange ; Danli Konga ; Yikai Zhouf ; Zhengxiang Liub ; Yuanling Dinga ; gdmcsbd@163.com" class="auth_mail" title="E-mail the corresponding author ; Dachun Yaoa ; dachun927@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Estrogen receptor ; Fatty acid metabolism ; Mitochondria ; Reactive oxygen species ; Vascular function
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：87
- 期：Complete
- 页码：92-101
- 全文大小：1624 K
文摘
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ERα responses E2-induced ERRα activation, while ERβ responses the basal expression.
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E2-induced ERRα expression in endothelium reduces the circulating lipids.
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ERRα expression on vascular wall normalizes E2-deficiency induced vascular function.
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ERRα knockdown in endothelium increases the blood pressure in high-fat diet mice.
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E2-induced ERRα expression plays important role in E2-induced vasculoprotective effect.