ERα responses E2-induced ERRα activation, while ERβ responses the basal expression.
E2-induced ERRα expression in endothelium reduces the circulating lipids.
ERRα expression on vascular wall normalizes E2-deficiency induced vascular function.
ERRα knockdown in endothelium increases the blood pressure in high-fat diet mice.
E2-induced ERRα expression plays important role in E2-induced vasculoprotective effect.