Established a reliable in vivo monitoring system for nitric oxide and reactive oxygen species.
Oxidative bursts occurs in the first few minutes of post-ischemia reperfusion with rapid loss of nitric oxide.
ERβ expression in endothelium increases the expression of ERRα, SOD2 and eNOS.
ERβ expression in endothelium minimizes ROS generation and mitochondrial dysfunction.
ERβ expression in endothelium ameliorates ischemia/reperfusion-mediated vascular injury.