ERβ expression in the endothelium ameliorates ischemia/reperfusion-mediated oxidative burst and vascular injury
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- 作者：Ying Zhana ; b ; 1 ; Zhaoyu Liub ; 1 ; Min Lia ; Ting Dingb ; Laxi Zhanga ; Qiaomei Lub ; Xu Liuc ; Ziyun Zhangb ; Athanasios Vlessidisd ; Tak Yee Awe ; Zhengxiang Liua ; b ; liuzhengxiang@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Dachun Yaoa ; b ; dachun927@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mitochondria ; Nitric oxide ; Oxidative stress ; SOD2 ; Vascular biology
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：223-233
- 全文大小：2260 K
文摘
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Established a reliable in vivo monitoring system for nitric oxide and reactive oxygen species.
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Oxidative bursts occurs in the first few minutes of post-ischemia reperfusion with rapid loss of nitric oxide.
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ERβ expression in endothelium increases the expression of ERRα, SOD2 and eNOS.
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ERβ expression in endothelium minimizes ROS generation and mitochondrial dysfunction.
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ERβ expression in endothelium ameliorates ischemia/reperfusion-mediated vascular injury.