Toxoplasma gondii inhibits differentiation of C17.2 neural stem cells through Wnt/β-catenin signaling pathway
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- 作者：Xiaofeng Gana ; 1 ; Xian Zhanga ; 1 ; Zhengyang Chenga ; Lingzhi Chena ; Xiaojuan Dinga ; Jian Duc ; Yihong Caid ; Qingli Luoa ; Jilong Shena ; Yongzhong Wangb ; yongzhong00@126.com" class="auth_mail" title="E-mail the corresponding author ; Li Yua ; lilyyu33@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Toxoplasma gondii ; C17.2 neural stem cells ; Differentiation ; Excreted-secreted antigens ; β-Catenin
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：22 April 2016
- 年：2016
- 卷：473
- 期：1
- 页码：187-193
- 全文大小：909 K
文摘
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Tg-ESAs significantly down-regulated the levels of βIII-tubulin and GFAP in C17.2 cells in a dose-dependent manner.
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Tg-ESAs significantly decreased β-catenin level in nucleus of C17.2 cells treated with wnt3a, an activator of Wnt pathway.
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A new mechanism for T. gondii infection-induced neuropathogenesis: blockade of Wnt/β-catenin pathway in NSCs by Tg-ESAs.