Design and synthesis of delivery system based on SBA-15 with magnetic particles formed in situ and thermo-sensitive PNIPA as controlled switch

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• 作者：Shenmin Zhu ; Zhengyang Zhou ; Di Zhang ; Chan Jin ; Zhiqiang Li
• 关键词：SBA-15 ; Controlled release ; PNIPA ; IBU
• 刊名：Microporous and Mesoporous Materials
• 出版年：2007
• 出版时间：1 November 2007
• 年：2007
• 卷：106
• 期：1-3
• 页码：56-61
• 全文大小：493 K

文摘

A novel responsive carrier system based on ordered mesoporous silica SBA-15 was synthesized, with magnetic particles formed in situ and thermo-sensitive poly(N-isopropyl acrylamide) (PNIPA) polymerized inside the pores. It was interesting to find that the obtained system held a relatively large pore diameter (3.8 nm) and pore volume (0.47 cm³ g⁻¹), which would benefit for drug storage with relatively large molecules. The delivery system displayed a hysteresis loop with a saturation magnetization (M_s) of 0.40 emu/g, which revealed the magnetic property of the prepared system. In vitro test of ibuprofen (IBU) loading and release exhibited a pronounced transition at around 17 °C, indicating a typical thermo-sensitive release property for this delivery system.