The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers
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- 作者：Leng Han1 ; 9 ; Lixia Diao1 ; 9 ; Shuangxing Yu2 ; 9 ; Xiaoyan Xu1 ; 3 ; 9 ; Jie Li2 ; Rui Zhang4 ; 10 ; Yang Yang1 ; 5 ; Henrica M.J. Werner2 ; 6 ; A. Karina Eterovic2 ; Yuan Yuan1 ; Jun Li1 ; Nikitha Nair7 ; Rosalba Minelli7 ; Yiu Huen Tsang7 ; Lydia W.T. Cheung2 ; Kang Jin Jeong2 ; Jason Roszik8 ; Zhenlin Ju1 ; Scott E. Woodman8 ; Yiling Lu2 ; Kenneth L. Scott7 ; Jin Billy Li4 ; Gordon B. Mills2 ; gmills@mdanderson.org" class="auth_mail" title="E-mail the corresponding author ; Han Liang1 ; 2 ; hliang1@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2015
- 出版时间：12 October 2015
- 年：2015
- 卷：28
- 期：4
- 页码：515-528
- 全文大小：2341 K
文摘
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A systematic analysis of genome-wide RNA editing events across tumor types was done
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A considerable number of clinically relevant RNA editing events are revealed
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The functional effects of cross-tumor nonsynonymous RNA editing events are shown
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Evidence that nonsynonymous RNA editing may affect drug sensitivity is provided