Cytotoxic ceramides and glycerides from the roots of Livistona chinensis

详细信息    查看全文

• 作者：Xiaobin Zeng^a ; Limin Xiang^a ; Chen-Yang Li^b ; Yihai Wang^a ; Guofu Qiu^a ; Zhen-xue Zhang^c ; ^{zhangzhenxue02@hotmail.com} ; Xiangjiu He^a ; ^{hexiangjiu@whu.edu.cn}
• 关键词：Livistona chinensis ; Ceramide ; Monoacylglycerol ; Diacylglycerol ; Antiproliferative activity
• 刊名：Fitoterapia
• 出版年：2012
• 出版时间：April, 2012
• 年：2012
• 卷：83
• 期：3
• 页码：609-616
• 全文大小：355 K

文摘

A 70 % ethanol extract of the roots of Livistona chinensis has been investigated, led to the isolation of 13 compounds, including a new ceramide, (2S,3S,4R,9Z)-2-[(2R)-2-hydroxytricosanoylamino]-9-octadecene-1,3,4-triol (2), a new glycosyl ceramide, 1-O-¦Â-d-glucopyranosyl-(2S,3S,4R,9Z)-2-[(2R)-2-hydroxydocosanoylamino]-9-octadecene-1,3,4-triol (3), three new monoacylglycerols, 1-(34-hydroxytetratriacontanoyl)-sn-glycerol (9), 1-[nonadeca-(9Z,12Z)-dienoyl]-sn-glycerol (10), and 1-[12-hydroxypentatriaconta-(13E,15Z)-dienoyl]-sn-glycerol (11), a new diacylglycerol, 1-(heptadeca-6Z,9Z-dienoyl)-3-(octadeca-6Z,9Z,12Z-trienoyl)-sn-glycerol (12), as well as a new diacylglycerol aminoglycoside, 1-octadecanoyl-2-nonadecanoyl-3-O-(6-amino-6-deoxy)-¦Â-d-glucopyranosyl-sn-glycerol (13). The structures of new compounds were elucidated, based on spectroscopic, zymologic and chemical methods. Among the compounds tested, compounds 3, 4 and 13 showed significantly antiproliferative effects against the human tumor cell lines (K562, HL-60, HepG2, and CNE-1) with the IC₅₀ of 10-65 ¦ÌM. To our knowledge, this is first report of the occurrence of ceramides and acylglycerols in the genus Livistona.