G protein coupled receptor kinase-2 upregulation causes κ-opioid receptor desensitization in diabetic heart

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• 作者：Xiyao Chen^a ; Shihao Zhao^b ; Yunlong Xia^b ; Zhenyu Xiong^b ; Yueyang Li^b ; Ling Tao^b ; Fuyang Zhang^b ; ^c ; ^{plazhangfuyang@163.com} ; Xiaoming Wang^a ; ^{xmwang@fmmu.edu.cn}
• 关键词：Diabetes ; Ischemia/reperfusion ; G protein coupled receptor kinase-2 ; κ-opioid receptor
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：658-664
• 全文大小：1364 K
• 卷排序：482

文摘

In type 1 diabetic mice, KOR is desensitized in the heart. Upregulation of GRK2 plays an essential role in cardiac KOR desensitization in diabetic mice. Inhibition of GRK2 is a novel and effective strategy to restore cardiac KOR sensitivity.