Simultaneous determination of ledipasvir, sofosbuvir and its metabolite in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study
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- 作者：Chenwei Pana ; Yongping Chenb ; Weilai Chenc ; Guangyao Zhoua ; Lingxiang Jina ; Yi Zhenga ; Wei Lina ; linwei196061@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhenzhen Panb ; wzzhenzhenpan@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ledipasvir ; Sofosbuvir ; GS-331007 ; UPLC&ndash ; MS/MS ; Plasma ; Pharmacokinetics
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：1008
- 期：Complete
- 页码：255-259
- 全文大小：822 K
文摘
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A method was validated to assay ledipasvir, sofosbuvir and its metabolite in plasma.
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The plasma sample was prepared by a protein precipitation.
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The method could also be used for clinical pharmacokinetic study.