Differential intracellular signalling properties of the growth hormone receptor induced by the activation of an anti-GHR antibody
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- 作者：Hainan Lana ; 1 ; Wei Lib ; 1 ; Zhiling Fua ; Yanhong Yanga ; Tiancheng Wua ; Yu Liua ; Hui Zhanga ; Huanzhong Cuia ; Yumeng Lia ; Pan Honga ; Jingsheng Liua ; ; Xin Zhenga ; zhengtougao@163.com" class="auth_mail
- 关键词：hGH ; human growth hormone ; GHR ; growth hormone receptor ; mAb ; monoclonal antibody ; FITC ; fluorescein isothiocyanate ; PBS ; phosphate-buffered saline ; TMB ; tetramethylbenzidine ; JAK ; Janus kinase ; STAT ; signal transducers and activators of transcription ; MAPK ; mitogen-activated protein kinase ; AKT ; protein kinase B
- 刊名：Molecular and Cellular Endocrinology
- 出版年：5 June 2014
- 年：2014
- 卷：390
- 期：1-2
- 页码：54-64
- 全文大小：1962 K
文摘
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CG-172 may serve as a signal-specific agonist.
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CG-172 may be an important tool to explore the mechanism of GHR signalling.
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CG-172 may be a valuable tool to explore the specific functions of GHR signalling.
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This study analyses why CG-172 is a signal-specific agonist.