Identification and differential expression of microRNAs associated with fat deposition in the liver of Wistar rats with nonalcoholic fatty liver disease
详细信息 查看全文
- 作者：Deqing Zhanga ; b ; Yuqian Wanga ; Zhibin Jia ; Zhonghua Wanga ; zhwang@sdau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：NAFLD ; nonalcoholic fatty liver disease ; miRNA ; microRNA ; GO ; gene ontology ; KEGG ; Kyoto Encyclopedia of Genes and Genomes ; TG ; triglycerides ; BGI ; Beijing genomics institute ; GEO ; gene expression omnibus ; NCBI ; national centers for bioinformatics information ; MFE ; minimum free energy ; TPM ; expression of transcripts per million
- 刊名：Gene
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：585
- 期：1
- 页码：1-8
- 全文大小：1009 K
文摘
- •
A Wistar rat model of NAFLD was successfully established.
- •
Three biological repetitions were performed to reduce the individual differences.
- •
Six small RNA libraries from NAFLD and normal rat liver tissue were constructed.
- •
Hundred and one differentially expressed miRNAs and 68 novel miRNAs were obtained.
- •
This is the first report on miRNA expression profiling of NAFLD rat liver tissues.