Nujiangexathone A, a novel compound from Garcinia nujiangensis, suppresses cervical cancer growth by targeting hnRNPK
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- 作者：Li Zhanga ; b ; c ; 1 ; Jiling Fenga ; c ; 1 ; Siyuan Konga ; c ; Man Wua ; c ; Zhichao Xia ; c ; Baojun Zhanga ; c ; Wenwei Fua ; c ; Yuanzhi Laoa ; c ; Hongsheng Tana ; c ; ths97029@163.com" class="auth_mail" title="E-mail the corresponding author ; Hongxi Xua ; b ; c ; xuhongxi88@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nujiangexathone A ; Garcinia species ; hnRNPK ; Cervical cancer ; Cell cycle
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：380
- 期：2
- 页码：447-456
- 全文大小：2674 K
文摘
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Recently, the protein hnRNPK has emerged as an important player in carcinogenesis process.
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The therapeutic strategies targeted on the protein hnRNPK are very limited.
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The effect of small molecules on hnRNPK protein hasn't been reported in cervical cancer.
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Our study indicated that NJXA showed antitumor effect in vitro and in vivo by targeting hnRNPK protein.
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NJXA is especially applicable as a potential candidate for treating cervical cancer with abnormally high hnRNPK expression.