Metabolomics approach to explore the effects of Kai-Xin-San on Alzheimer’s disease using UPLC/ESI-Q-TOF mass spectrometry
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- 作者：Hang Chu ; Aihua Zhang ; Ying Han ; Shengwen Lu ; Ling Kong ; Jinwei Han ; Zhidong Liu ; Hui Sun ; Xijun Wang ; wangxijunomics@126.com" class="auth_mail" title="E-mail the corresponding author ; xijunwangls@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer&rsquo ; s disease ; Metabolomics ; Kai-Xin-San ; SYNAPT G2-Si HDMS ; Traditional chinese medicine
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：1015-1016
- 期：Complete
- 页码：50-61
- 全文大小：4289 K
文摘
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Metabolic profiling was restored to their baseline values after Kai-Xin-San treatment.
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The alterations were glycerophospholipid metabolism, sphingolipid metabolism, etc.
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Kai-Xin-San has protective effects through regulating the perturbed pathway.
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This study successfully demonstrated the power of metabolomics in TCM.