CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer
详细信息 查看全文
- 作者：Yubao Wang1 ; 2 ; 7 ; Tinghu Zhang1 ; 2 ; 7 ; Nicholas Kwiatkowski3 ; 7 ; Brian J. Abraham3 ; Tong Ihn Lee3 ; Shaozhen Xie1 ; 2 ; Haluk Yuzugullu1 ; 2 ; Thanh Von1 ; 2 ; Heyuan Li1 ; Ziao Lin1 ; Daniel G. Stover4 ; Elgene Lim4 ; Zhigang C. Wang1 ; 5 ; J. Dirk Iglehart1 ; 5 ; Richard A. Young3 ; 6 ; 8 ; Nathanael S. Gray1 ; 2 ; 8 ; nathanael_gray@dfci.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Jean J. Zhao1 ; 2 ; 8 ; jean_zhao@dfci.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2015
- 出版时间：24 September 2015
- 年：2015
- 卷：163
- 期：1
- 页码：174-186
- 全文大小：3367 K
文摘
- •
Triple-negative breast cancer (TNBC) cells are highly dependent on CDK7
- •
CRISPR/Cas9-mediated gene editing shows selective dependency of TNBC on CDK7
- •
CDK7 activity is critical for the expression of a set of genes essential for TNBC
- •
A covalent CDK7 inhibitor blocks tumor growth in patient-derived xenografts of TNBC